@incollection{ls_leimeister,
  address = {Wiesbaden, Germany (to appear)},
  author = {Prinz, A. and Menschner, P. and Koene, P. and Köbler, F. and Krcmar, H. and Leimeister, J. M.},
  booktitle = {Personenbezogene Dienstleistungen im Kontext komplexer Wertschöpfungssysteme – Anwendungsfeld „seltene Krankheiten“},
  editor = {Geiger, M. and Bieber, D.},
  interhash = {da7bc0d0aeb8d643a56ab8ed973516c2},
  intrahash = {0da29fae21f94f5198f7758f7ea06bd1},
  note = 376,
  publisher = {Gabler Verlag},
  title = {Verknüpfung von Dienstleistungselementen mit Hilfe von Near Field Communication},
  year = 2013
}

@incollection{ls_leimeister,
  address = {Wiesbaden, Germany (to appear)},
  author = {Hartmann, M. and Prinz, A. and Leimeister, J. M.},
  booktitle = {Personenbezogene Dienstleistungen im Kontext komplexer Wertschöpfungssysteme – Anwendungsfeld „seltene Krankheiten“},
  editor = {Geiger, M. and Bieber, D.},
  interhash = {ee3cc75b1ba0d135b378805fc01bf746},
  intrahash = {135fcbe2572a28eb25f2c6da6b2a3b96},
  note = 375,
  publisher = {Gabler Verlag},
  title = {Communities für Innovationen – Modulare Erweiterung einer Patientencommunity zur Ideenschmiede},
  year = 2013
}

@inproceedings{ls_leimeister,
  address = {Berlin, Germany},
  author = {Heußner, M. and Ackermann, L. and Widy, O. and Schmidt, L. and Pippert, M. and Bienhaus, D. and Durward, D. and Prinz, A. and Wegener, R. and Leimeister, J.M.},
  booktitle = {6. Deutscher AAL-Kongress 2013 - Themenschwerpunkt: AAL in der gesundheitlichen Versorgungskette: Zuhause – Unterwegs – im Krankenhaus – in der Reha – in der Pflege – im Hospiz },
  interhash = {45c5b8b92b496a3d98a94c5266fc3ca9},
  intrahash = {59b6c12fb12fa66f7b8ff066e04f9fdd},
  note = 367,
  title = {AAL-Weiterbildung für Pflege und Handwerk: erste Ergebnisse einer Anforderungsanalyse},
  year = 2013
}

@techreport{neubauer2011proteine,
  author = {Neubauer, U. and Bertinetti, D. and Prinz, A. and Herberg, F. W.},
  editor = {Hessen-Biotech, Aktionslinie},
  institution = {Hessen-Biotech NEWS},
  interhash = {270cb7f9cd848f2ab91735cea38940c2},
  intrahash = {104afb4292007b138507c617912a4885},
  journal = {Hessen-Biotech NEWS},
  number = 2,
  pages = {14-15},
  title = {Proteine bei der Arbeit beobachten},
  url = {http://www.hessen-biotech.de/mm/Hessen_biotech_NEWS2_2011.pdf},
  year = 2011
}

@article{kummer2012structural,
  abstract = {We have selected designed ankyrin repeat proteins (DARPins) from a synthetic library by using ribosome display that selectively bind to the mitogen-activated protein kinase ERK2 (extracellular signal-regulated kinase 2) in either its nonphosphorylated (inactive) or doubly phosphorylated (active) form. They do not bind to other kinases tested. Crystal structures of complexes with two DARPins, each specific for one of the kinase forms, were obtained. The two DARPins bind to essentially the same region of the kinase, but recognize the conformational change within the activation loop and an adjacent area, which is the key structural difference that occurs upon activation. Whereas the rigid phosphorylated activation loop remains in the same form when bound by the DARPin, the more mobile unphosphorylated loop is pushed to a new position. The DARPins can be used to selectively precipitate the cognate form of the kinases from cell lysates. They can also specifically recognize the modification status of the kinase inside the cell. By fusing the kinase with Renilla luciferase and the DARPin to GFP, an energy transfer from luciferase to GFP can be observed in COS-7 cells upon intracellular complex formation. Phosphorylated ERK2 is seen to increase by incubation of the COS-7 cells with FBS and to decrease upon adding the ERK pathway inhibitor PD98509. Furthermore, the anti-ERK2 DARPin is seen to inhibit ERK phosphorylation as it blocks the target inside the cell. This strategy of creating activation-state-specific sensors and kinase-specific inhibitors may add to the repertoire to investigate intracellular signaling in real time.},
  author = {Kummer, L. and Parizek, P. and Rube, P. and Millgramm, B. and Prinz, A. and Mittl, P. R. and Kaufholz, M. and Zimmermann, B. and Herberg, F. W. and Plückthun, A.},
  doi = {10.1073/pnas.1205399109},
  interhash = {d2c682d22f697c85a0a4d46b35c28867},
  intrahash = {80b42ef636509d9370692455cfc7a5bb},
  journal = {Proc Natl Acad Sci U S A},
  month = jul,
  pmid = {22843676},
  title = {Structural and functional analysis of phosphorylation-specific binders of the kinase ERK from designed ankyrin repeat protein libraries},
  url = {http://www.ncbi.nlm.nih.gov/pubmed/22843676},
  year = 2012
}

@inproceedings{diskar2005investigating,
  author = {Diskar, M. and Herberg, F. W. and Prinz, A.},
  interhash = {09f9a8a93396596add8cce2554129117},
  intrahash = {4aa07ee13bfbe9fcad329cc1a584953b},
  issn = {{1742-464X}},
  journal = {FEBS JOURNAL},
  month = jul,
  note = {{IUBMB 50th Anniversary Symposium, Budapest, HUNGARY, JUL 02-07, 2005}},
  number = 1,
  pages = 303,
  times-cited = {{0}},
  title = {Investigating human protein kinase X holoenzyme formation using bioluminescence resonance energy transfer (BRET)},
  unique-id = {{ISI:000234826101555}},
  volume = 272,
  year = 2005
}

@article{ls_leimeister,
  author = {Prinz, A. and Menschner, P. and Leimeister, J. M.},
  interhash = {ae03c6724e33b330c8727a33f428021a},
  intrahash = {7f555f7a0e290668d041334909d80f0d},
  journal = {Health Policy and Technology},
  note = 341,
  number = 3,
  title = {Electronic Data Capture in HealthCare - NFC as Easy Way for Self reported Health Status Information},
  url = {http://pubs.wi-kassel.de/wp-content/uploads/2013/03/JML_334.pdf},
  volume = 1,
  year = 2012
}

@inproceedings{ls_leimeister,
  address = {Braunschweig, Germany},
  author = {Hartmann, M. and Bretschneider, U. and Prinz, A. and Leimeister, J. M.},
  booktitle = {Informatik 2012 - Game IT: Der Einsatz von IT-basierten Spielen und Spielmechaniken im organisationalen Kontext},
  interhash = {529e27197e7c75b91dabe78cf3506cb9},
  intrahash = {c29b31e7e6fb8467d4c7e547f55fc387},
  note = 335,
  title = {Patienten als Innovatoren – Eine modulare Erweiterung einer Patientencommunity zur Ideenschmiede},
  url = {http://pubs.wi-kassel.de/wp-content/uploads/2013/03/JML_356.pdf},
  year = 2012
}

@article{ls_leimeister,
  address = {Heidelberg, Germany },
  author = {Prinz, A. and Leimeister, J. M.},
  interhash = {10ce04c08cf30cc2bb5bb3112780a317},
  intrahash = {171918441b52bcc337f5dc29d3ed8fce},
  journal = {HMD Praxis der Wirtschaftsinformatik},
  month = {August},
  note = 322,
  pages = {73-82},
  publisher = {dpunkt Verlag},
  title = {Mobile Systeme im Gesundheitswesen - NFC-basiertes Electronic Data Capturing},
  url = {http://pubs.wi-kassel.de/wp-content/uploads/2013/03/JML_333.pdf},
  volume = 286,
  year = 2012
}

@article{parizek2012designed,
  abstract = {The c-Jun N-terminal kinases (JNKs) are involved in many biological processes such as proliferation, differentiation, apoptosis and inflammation and occur in highly similar isoforms in eukaryotic cells. Isoform-specific functions and diseases have been reported for individual JNK isoforms mainly from gene-knockout studies in mice. There is, however, a high demand for intracellular inhibitors with high selectivity to improve the understanding of isoform-specific mechanisms and for use as therapeutic tools. The commonly used JNK inhibitors are based on small molecules or peptides which often target the conserved ATP binding site or docking sites and thus show only moderate selectivity. To target novel binding epitopes, we used Designed Ankyrin Repeat Proteins (DARPins) to generate alternative intracellular JNK inhibitors that discriminate two very similar isoforms, JNK1 and JNK2. DARPins are small binding proteins that are well expressed, stable and cysteine-free, which makes them ideal candidates for applications in the reducing intracellular environment. We performed ribosome display selections against JNK1α1 and JNK2α1 using highly diverse combinatorial libraries of DARPins. The selected binders specifically recognize either JNK1 or JNK2 or both isoforms in vitro and in mammalian cells. All analyzed DARPins show affinities in the low nanomolar range and isoform-specific inhibition of JNK activation in vitro at physiological ATP concentrations. Importantly, DARPins that selectively inhibit JNK activation in human cells were also identified. These results emphasize the great potential of DARPins as a novel class of highly specific intracellular inhibitors of distinct enzyme isoforms for use in biological studies and as possible therapeutic leads.},
  author = {Parizek, P and Kummer, L and Rube, P and Prinz, A and Herberg, F W and Pl{\"u}ckthun, A},
  doi = {10.1021/cb3001167},
  interhash = {105f4d4b50989395d30b09b306f4aa84},
  intrahash = {b4bb2d16ce8c319692aef95ff8fced40},
  journal = {ACS Chem Biol},
  month = may,
  pmid = {22568706},
  title = {Designed Ankyrin Repeat Proteins (DARPins) as Novel Isoform-specific Intracellular Inhibitors of c-Jun N-terminal Kinases},
  url = {http://www.ncbi.nlm.nih.gov/pubmed/22568706},
  year = 2012
}

@misc{prinz2010qualitative,
  author = {Prinz, A.},
  howpublished = {habilitation treatise},
  interhash = {24acc9cfc9954a1f1fcd73c1fbca78af},
  intrahash = {f1a28881fc1ac55763e5574778e94233},
  school = {Universität Kassel},
  title = {Qualitative und quantitative Analyse von Protein-Protein Wechselwirkungen in der cAMP-vermittelten Signaltransduktionskaskade mittels Biolumineszenz Resonanz Energie Transfer},
  year = 2010
}

@incollection{menschner2012service,
  address = {Wiesbaden, Germany},
  author = {Menschner, P. and Prinz, A. and Leimeister, J.M.},
  booktitle = {Technologiegestützte Dienstleistungsinnovation in der Gesundheitswirtschaft},
  editor = {Shire, K.A. and Leimeister, J.M.},
  interhash = {71f8605dc8acd5dfd157200263c0141f},
  intrahash = {a0933a587752f2c9cc6d3d35e5d32cbc},
  note = 315,
  pages = {111-133},
  publisher = {Gabler Verlag},
  title = {Service Engineering für IT-basierte Dienstleistungen 50+},
  url = {http://pubs.wi-kassel.de/wp-content/uploads/2013/03/JML_336.pdf},
  year = 2012
}

@inproceedings{ls_leimeister,
  address = {Barcelona, Spain},
  author = {Prinz, A. and Menschner, P. and Leimeister, J. M.},
  booktitle = {Proceedings of the 20th European Conference on Information Systems (ECIS)},
  interhash = {e8481b7189df7aaceefcca61422305c1},
  intrahash = {8bdb2c30e5726163090575b827af4935},
  note = 309,
  title = {NFC-based Electronic Data Capture Systems – The Case of a Quality of Life Questionnaire},
  url = {http://pubs.wi-kassel.de/wp-content/uploads/2013/03/JML_332.pdf},
  year = 2012
}

@article{murdoch2011interaction,
  abstract = {LIS1, a WD40 repeat scaffold protein, interacts with components of the cytoplasmic dynein motor complex to regulate dynein-dependent cell motility. Here, we reveal that cAMP-specific phosphodiesterases (PDE4s) directly bind PAFAH1B1 (also known as LIS1). Dissociation of LIS1-dynein complexes is coupled with loss of dynein function, as determined in assays of both microtubule transport and directed cell migration in wounded monolayers. Such loss in dynein functioning can be achieved by upregulation of PDE4, which sequesters LIS1 away from dynein, thereby uncovering PDE4 as a regulator of dynein functioning. This process is facilitated by increased intracellular cAMP levels, which selectively augment the interaction of long PDE4 isoforms with LIS1 when they become phosphorylated within their regulatory UCR1 domain by protein kinase A (PKA). We propose that PDE4 and dynein have overlapping interaction sites for LIS1, which allows PDE4 to compete with dynein for LIS1 association in a process enhanced by the PKA phosphorylation of PDE4 long isoforms. This provides a further example to the growing notion that PDE4 itself may provide a signalling role independent of its catalytic activity, exemplified here by its modulation of dynein motor function.},
  author = {Murdoch, H. and Vadrevu, S. and Prinz, A. and Dunlop, A. J. and Klussmann, E. and Bolger, G. B. and Norman, J. C. and Houslay, M. D.},
  doi = {10.1242/jcs.082982},
  interhash = {bdf602046d54699723074c9fbde1a599},
  intrahash = {52cdbaae27bb980953013f136f366623},
  journal = {J Cell Sci},
  month = jul,
  number = {Pt 13},
  pages = {2253-2266},
  pmid = {21652625},
  title = {Interaction between LIS1 and PDE4, and its role in cytoplasmic dynein function},
  url = {http://www.ncbi.nlm.nih.gov/pubmed/21652625},
  volume = 124,
  year = 2011
}

@inproceedings{ls_leimeister,
  address = {Berlin, Germany},
  author = {Koene, P. and Köbler, F. and Menschner, P. and Altmann, M. and Prinz, A. and Leimeister, J. M. and Krcmar, H.},
  booktitle = {3. Deutscher AAL-Kongress 2010},
  interhash = {2a7dccd03ceec8e0d1016a6a2d066801},
  intrahash = {c75da5ebc1d726139c2f6700f62cf57f},
  note = {159 (7-10)},
  title = {Participatory Requirements Analysis: Entwicklung innovativer NFC- und IT-basierter Care-Dienstleistungen für 50+},
  url = {http://www.uni-kassel.de/fb7/ibwl/leimeister/pub/JML_148.pdf},
  volume = 3,
  year = 2010
}

@inproceedings{ls_leimeister,
  address = {Hagenberg, Austria (accepted for publication)},
  author = {Prinz, A. and Menschner, P. and Altmann, M. and Leimeister, J. M.},
  booktitle = {3. International Workshop on Near Field Communication (NFC) 2011},
  interhash = {672bfc7cc3e43486f9324ff21c9afae5},
  intrahash = {48886111555411303ca6e47a4befc39a},
  note = {209 (01-11)},
  number = 3,
  title = {inSERT - a NFC-based Self-Reporting Questionnaire for Patients with Fine Motor Diseases},
  year = 2011
}

@article{ls_leimeister,
  author = {Wegener, R. and Prinz, A. and Gerhold, R. and Oeste, S. and Leimeister, J. M.},
  interhash = {4d9c092af1fa59169e2ffbed78d77e10},
  intrahash = {dd8d203007b81e1935a7b811b0b7d923},
  journal = {Hamburger eLearning-Magazin},
  note = {217 (62-10)},
  number = 5,
  title = {eLearning Konsumenten zu eLearning Autoren machen - Erfahrungen an der Universität Kassel},
  url = {http://www.uni-kassel.de/fb7/ibwl/leimeister/pub/JML_217.pdf},
  year = 2010
}

@inproceedings{ls_leimeister,
  address = {Berlin, Germany},
  author = {Prinz, A. and Menschner, P. and Altmann, M. and Leimeister, J. M. and Koene, P. and Köbler, F. and Krcmar, H. and Linke, P. and Maier, A. and Holm, T. and Meyer, T.},
  booktitle = {3. Deutscher AAL-Kongress 2010},
  interhash = {aaa83122d39bd65bd2389686b9dbc84d},
  intrahash = {3dc9aab4d97e2fadfe53fbb0c8e1aab1},
  note = {158 (6-10)},
  title = {Mobiles Ernährungsmanagement am Beispiel ALS-bedingter Mangelernährung},
  url = {http://www.uni-kassel.de/fb7/ibwl/leimeister/pub/JML_149.pdf},
  year = 2010
}

@inproceedings{ls_leimeister,
  address = {Wiesbaden, Germany (to appear)},
  author = {Maier, A. and Holm, T. and Linke, P. and Münch, C. and Leimeister, J. M. and Prinz, A. and Steinfurth, L. and Meyer, T.},
  booktitle = {84. Kongress der Deutschen Gesellschaft für Neurologie},
  interhash = {7fef5bf519c30fd658fb92edab8801d3},
  intrahash = {19245cf99c64a9773154f2e6943e1783},
  note = {232 (18-11)},
  number = 84,
  title = {NFC-gestützte Selbstbewertung von Symptomen bei der ALS},
  year = 2011
}

@inproceedings{ls_leimeister,
  address = {Zürich, Schweiz},
  author = {Hartmann, M. and Prinz, A. and Hirdes, E. and Görlitz, R. and Rashid, A. and Weinhardt, C. and Leimeister, J. M.},
  booktitle = {Wirtschaftsinformatik Konferenz (WI) 2011},
  interhash = {eb6b86be78685402c244bc0eb06bcefc},
  intrahash = {4ba839258e796c07068d6d25df3e7a47},
  note = {210 (02-11)},
  title = {Web 2.0 im Gesundheitswesen –  Ein Literature Review zur Aufarbeitung aktueller Forschungsergebnisse zu Health 2.0 Anwendungen},
  url = {http://www.uni-kassel.de/fb7/ibwl/leimeister/pub/JML_210.pdf},
  volume = 10,
  year = 2011
}